Born in 1884, Cornelia Otis Skinner grew up in New York City. She attended Radcliffe College, where she received her A.B. degree in 1911. Her first job was as a stenographer for the League of Nations in Washington, D.C
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She met her future husband, George Lyman Kittredge, who was then an assistant professor of history at Harvard University, while visiting his home in Cambridge, Mass., and the two were married in 1915 while he was still on active duty with the United States Navy during World War I. At that time Mr. Kittredge was stationed at the Naval Training Station at Newport, Rhode Island.
Mrs. Kittredge accompanied her husband to Rhode Island when he took his leave of active duty after the war ended in 1919 and she also remained there while her husband taught at the Massachusetts Institute of Technology.